Nanda and Yadav, 2003

From
Nanda, S. and Yadav, J.S. (2003) Lipoxygenase biocatalysis: a survey of asymmetric oxygenation. J. Molec. Cat B: Enzym. 26, 3-28.
Authors
Nanda is from the Department of Chemistry, Center for Biological NMR, at the Texas A&M University; Yadav is from the Organic Division of the IICT, India
Audience
This literature review was written specifically for enzymologists and biochemists that are studying lipoxygenase biocatalysis.
Topic
Review of the different substrates that can be utilized by lipoxygenase (LOX) and recent work. It is interested particularly at the bioconversion of different substrates. It covers the different substrates that have been used and has a specific section for novel substrates. It also includes some general consideration and was has been done in terms of facilitating this bioconversion using different strategies such as immobilization and non-conventional media.
Purpose
The last reviews published on the lipoxygenase enzyme dated from 1995 and concentrated on the soybean or plant isozymes. Since then, different groups (such as our group!) have work on LOX using other sources of enzymes and in different environments.
Rationale
As many groups are working in this field in general and it has changed a lot in recent years, it is interesting to get a review covering some specific aspects suh as substrate specificity of LOX.
Comment/Idea
Could help to contextualize a future review that could be produced on the subject. Something like the recent trends and developments in LOX biocatalysis would be a different angle to be taken. Or even more general like the use of immobilization and non-conventional media in the lipoxygenase pathway (which would also include hydroperoxide lyase).

Outline of the review:
Introduction
Fatty acids as lipoxygenase substrates
Linoleic acid
Linolenic acid
Arachidonic acid
Novel substrates and products of lipoxygenase catalysis
Synthetic use of lipoxygenase
Designed substrate for lipoxygenase catalysisRegiochemical consideration
Role of hydrophobicity
Role of pH
Effect of oxygen concentration
Enantioselectivity in LOX catalysis
LOX biocatalysis in non-conventional medium
Biocatalysis with immobilized LOX
Biocatalysis with recombinant LOX
Total synthesis using LOX catalysisConclusion